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KMID : 0191120070220061079
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Journal of Korean Medical Science
2007 Volume.22 No. 6 p.1079 ~ p.1081
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Therapeutic Experience of Bing-Neel Syndrome Associated with Waldenstrom’s Macroglobulinemia
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Kim Hyun-Do
Shin Kyeong-Cheol
Cho Hee-Soon
Kim Min-Kyoung
Lee Kyoung-Hee
Hyun Myung-Soo
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Abstract
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Waldenstrom’s macroglobulinemia is an uncommon low-grade B-cell lymphoproliferative disorder in which monoclonal immunoglobulin M is produced. Neurological symptoms due to hyperviscosity are frequent manifestations of Waldenstrom’s macroglobulinemia. However, central nervous system infiltration by plasmacytoid lymphocytes (Bing-Neel syndrome) has only rarely been reported. We report a case of a 51-yr-old woman suffering from Waldenstrom’s macroglobulinemia who complained of persistant headache. Brain magnetic resonance imaging revealed an extra-axial soft tissue mass along the left cavernous sinus, left tentorium, right tentorium, and falx cerebri. A stereotactic biopsy of dural tissue from the falx was performed and showed plasmacytoid lymphocyte infiltration. The patient became symptom- free with irradiation of the whole brain followed by chemotherapy with fludarabine.
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KEYWORD
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Waldenstrom’s Macroglobulinemia, Central Nervous System
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